Inactivation of Purified Human a2-Antiplasmin and Purified Human Cl Inhibitor by Synthetic Fibrinolytic Agents
نویسندگان
چکیده
3-Hydroxypropyl flufenamide (Flu-HPA) is one of a series of flufenamic acid derivatives that enhances blood clot lysis in vitro. Studies of possible mechanisms of action of FIu-HPA were undertaken. The profibrinolytic activity of FIu-HPA in clot lysis assays was found to be dependent on plasminogen. The influence of FIu-HPA on the ability of purified a2-antiplasmin to inhibit purified plasmin was studied. Plasmin activity was determined using 125l-fibrin plates or the spectrophotometric tripeptide substrate. Val-Leu-Lys-paranitroanilide. At FIu-HPA concentrations greater than 1 mM. the inhibitory activity of a2-antiplasmin was abolished in a time-dependent and concentrationdependent manner. The influence of Flu-HPA on the ability of purified CI inhibitor to inhibit purified plasma kallikrein
منابع مشابه
Inactivation of purified human alpha 2-antiplasmin and purified human C1 inhibitor by synthetic fibrinolytic agents.
3-Hydroxypropyl flufenamide (Flu-HPA) is one of a series of flufenamic acid derivatives that enhances blood clot lysis in vitro. Studies of possible mechanisms of action of Flu-HPA were undertaken. The profibrinolytic activity of Flu-HPA in clot lysis assays was found to be dependent on plasminogen. The influence of Flu-HPA on the ability of purified alpha 2-antiplasmin to inhibit purified plas...
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